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Research backs this up: when using GLP-1s to aid in weight loss, they were found to effectively reduce BMI, triglycerides, waist circumference, and total testosterone in people with PCOS, according to a 2024 meta-analysis in the Journal of Diabetes and its Complications

Additionally, two cohort studies reported that metformin use significantly lowered the risk of total joint replacement in patients with type 2 diabetes (Fig

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While no confirmed human harm has been reported, animal studies showed increased risk of fetal abnormalities at therapeutic doses, which is why discontinuation two months before conception is the standard recommendation

The latter is a secondary messenger involved in calcium mobilization, cell cycle control, and insulin signaling