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Ammonia readily crosses the blood-brain barrier and is thought to inhibit glutamate uptake, thereby increasing extracellular glutamate concentrations in the brain and resulting in activation of NMDA receptors

Neuroscience 385 , 227236 (2018)

This phenomenon, known as reperfusion injury, involves the oxidation of cellular components, mitochondrial dysfunction, and the activation of inflammatory pathways [91, 92]

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The study was presented as an abstract at the Experimental Biology international conference, in San Diego, on April, 4 th , 2016: Zavorsky G.S, Ueberschlag S.L., Seay J.R, Roberts A.H., DeSpirito P.C., Stith J.M., Folz R.J., Carter K.A., Weiss, E.P