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This is mechanistically demonstrated in breast cancer models, where SFN, by activating the Nrf2 pathway, reduces the secretion of prostaglandin E2 (PGE2) from tumor cells, thereby triggering MDSCs to switch from an immunosuppressive to an immunogenic phenotype and inhibiting their expansion (76)

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Understanding this timeline helps set realistic expectations and determine whether observed changes represent expected gradual decline or concerning rapid reversal suggesting dependency or underlying issues

12 Another study looked at 5mg of melatonin nightly in people with endometriosis-associated chronic pelvic pain