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Even partial freezing, where ice crystals form and then thaw, can cause irreversible damage

If your primary goal is not weight loss: GLP-1 medications show promise beyond weight management

After the initial rapid drop in weight, you may notice the rate of weight loss starting to slow down, especially between 12 and 36 weeks

Other Considerations Pancreatitis represents a rare but serious potential concern with all incretin-based medications

Orforglipron (Foundayo) Orforglipron (Foundayo) is GLP-1 receptor agonist

Factors favoring earlier intervention include strong family history of diabetes, multiple metabolic risk factors, prior gestational diabetes, or failed lifestyle modification attempts