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Endogenous GHK-Cu levels have been observed to decline with age, a pattern that Pickart and colleagues hypothesized contributes to impaired wound healing and skin repair, though precise reference-range values have not been firmly established in large population studies (Pickart 1973, cited in multiple reviews)

untreated hypothyroidism can blunt GH response [5]

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This helps your provider determine if the medication is appropriate for you