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Experimentally, the released active agent is optionally fitted to the Korsmeyer-Peppas equation Q/Q =kt n +b where Q is the amount of active agent released at time t, Q is the overall released amount of active agent, k is a release constant of the nth order, n is a dimensionless number related to the dissolution mechanism, and b is the axis intercept, characterizing the initial burst release mechanism wherein n=1 characterizes an erosion controlled mechanism

Coffin, College of Arts and Sciences, Washington State University, 14204 NE Salmon Creek Avenue, Vancouver, WA 98686-9600, USA e-mail: [email protected] This article was submitted to the journal Frontiers in Cellular Neuroscience

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Neuron 110 , 516531.e6 (2022)