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For instance, combining SGLT2 inhibitors or GLP-1 agonists with metformin can lower systolic blood pressure by 3 to 5 mmHg

Direct head-to-head Phase 3 data does not yet exist

Serious side effects and warnings Retatrutide does not currently have an FDA-approved boxed warning, contraindication section, or final adverse-reaction profile because it is not FDA-approved

Significant weight loss, on average of 5-10% of body weight (10-25 pounds in some patients) within the first 3 months of usage

Disclaimer: This article was prepared by Jenna Ogilvie, Ogilvie Editorial, and reviewed by Alex Azar , Jaime Almandoz, Govind Persad, Jeffrey Singer, and Tracy Zvenyach