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Heat therapy, gentle stretching, rest, and over-the-counter topical creams containing menthol or capsaicin can address localized muscle or joint pain without systemic drug interactions

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Conversely, drugs that exclusively targeted pathways absent from the comorbidity network were omitted from the analysis

These include cardiovascular protection, neuroprotection, and metabolic regulation, which can influence conditions such as polycystic ovary syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD), and osteoporosis

Mechanistic studies examine its interactions with nitric oxide signaling, prostaglandin pathways, and gastrointestinal dopamine and serotonin turnover, including their relevance to experimental models of intestinal inflammation and gastrointestinal dysfunction

124 Jagdhuhn, D