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According to the CDC, at least 1 in 4 adults in every U.S

Jones JL, Fernandez ML, McIntosh MS, et al

After 4 weeks, doses may be increased in 2.5 mg increments, as tolerated, up to a maximum of 15 mg once weekly

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Interestingly, higher GGT values were associated with an increased risk of incident T2D even among individuals with ALT or AST below the median levels

Thus, the clinical and experimental studies convincingly show the involvement of mitochondrial abnormalities in RS, although the mechanisms underlying the role of mitochondrial dysfunction need further investigation