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Other GLP-1 receptor peptides offer additional insights into the evolving landscape of metabolic disease treatment
8 Participants not using CPAP were enrolled in trial 1 (234 participants), and those using CPAP were enrolled in trial 2 (235 participants)
Tesofensine produced weight loss significantly greater than placebo and was more effective than any currently approved obesity drug at the time. Astrup et al., The Lancet Additional Findings: The majority of weight loss came from visceral fat and abdominal adiposity Lean body mass was preserved , unlike with most appetite suppressants Participants reported reduced hunger and better diet adherence Tesofensine significantly improved waist circumference , lipid profiles, and fasting glucose These findings have led to continued interest in Tesofensines use for body recomposition not just for general weight loss, but for fat-specific reduction without muscle sacrifice
That period crystallised something I had been circling as a formulator
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