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Like autoantibodies, Hcy can also activate AT1Rs (angiotensin II type 1 receptors) (Li et al., 2018)

Buse, M.D., from the University of North Carolina School of Medicine in Chapel Hill, and colleagues randomly assigned 2,713 adults with inadequately controlled type 2 diabetes receiving metformin with or without SGLT2i with overweight or obesity to receive cagrilintide-semaglutide, semaglutide, cagrilintide, or placebo for 68 weeks

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plan sponsors can consider implementing try and fail step therapy rules so that less expensive generic medications with a history of reducing A1C are used as the first line option with close patient monitoring, as clinically appropriate