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Third, although the study used a rat model and the ATDC5 cell line to mimic the OA situation, these models may not fully reflect the complexity of human OA pathology and drug metabolism

The SLC7A11-containing cystine/glutamate antiporter system xc supports cysteine availability after imported cystine is reduced, although its contribution depends on nutrient conditions and transporter expression (Jyotsana et al., 2022)

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Nausea and gastrointestinal symptoms peak during weeks 6-8, then improve substantially by week 12