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139 Uricosuric agents represent a secondary or alternative therapeutic option, with recent guidelines advocating their use in combination with XO inhibitors when monotherapy proves ineffective

Storage & Handling: Store lyophilized peptide at -20C

In this context, elegant studies published by Ira Tabass group have contributed to the understanding of cellular metabolism by demonstrating that macrophages use amino acids, such as arginine and ornithine, derived from the degradation of ACs to synthesize putrescine that activates Rac1, which stabilizes the machinery required for actin remodeling and plasma membrane projection, supporting continuous efferocytosis

Our data showed that a mix of these complementary substances was greatly effective in improving metabolic parameters