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Among patients without diabetes, the pattern differed from patients with type 2 diabetes: patients on a GLP-1 who maintained a stable weight had a higher osteoporosis risk relative to those who maintained a stable weight on another weight loss medication (22.0% higher for GLP-1 users)

& Trautmann, M

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Studies show that patients who maintain lifestyle changes (reduced calorie intake, regular movement) experience slower weight rebound even after GLP-1 medications leave their system