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Patients reporting "significant energy improvement" rate injections as worth the cost at 2.4x the rate of those reporting "mild improvement." Comparison to alternatives: MIC B12 injections occupy a middle ground: more effective than oral supplementation for B12 repletion and subjective energy, less effective than prescription weight-loss medications for weight reduction, and significantly less expensive than GLP-1 agonists

doi: 10.3389/fimmu.2016.00273 54 BraankerHdBongenaarMLubbertsE

B12-deficiency symptoms in the infants improved (Srikantia, 1967)

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Still, any time you put a needle in your arm or glute (common injection sites), theres a risk of some swelling at the site