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Lifestyle fundamentals still rule as the most important sustainable body composition change drivers

Genetic variants in pathways controlling appetite, glucose regulation, and metabolic rate (such as GLP1R rs6923761, GIPR rs1800437, and FTO rs9939609) may influence how a person's body responds to GLP-1 therapy

Additionally, new research indicates that tirzepatide potentially has some advantages over traditional metabolic regulation, such as insulin sensitivity improvement and anti-inflammatory effect [2]

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It showed that a lot of the lean mass lost was in organs, like the liver, which lost fat mass (decreased fatty liver)