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At the intranasal doses used in Schneider-Helmert's human protocols (roughly 25 to 30 nmol/kg), the resulting total dose for an average adult falls in the low-to-mid microgram range, substantially less than the milligram-level doses commonly sold in single vials

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A 2024 meta-analysis of 12 randomized controlled trials involving 498 individuals with ASD found that higher doses of intranasal oxytocin (48 IU/day) were associated with improvements in social functioning and repetitive behaviors

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