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eNOS uncoupling Under certain conditions, eNOS can become uncoupled, shifting from producing NO to generating superoxide (O 2 ), which not only reduces NO availability but also increases oxidative stress, reducing endothelial dysfunction

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Members of this family are leukotriene C-4 synthase, 5-lipoxygenase activating protein, prostaglandin E synthase, and microsomal glutathione S-transferases (MGST) 1, 2 and 3 [198,199]

Incorporating stress-reducing practices, such as meditation, deep-breathing exercises, or hobbies that bring joy, can help maintain balanced glutathione levels

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