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Hypokalemia and sudden death may occur in severe megaloblastic anemia which is treated intensely with vitamin B12

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B12 is water-soluble, and its generally safe even at very high doses

Hashimotos thyroiditis (HT) is an organ-specific autoimmune disease that disrupts thyroid hormone production and typically progresses to hypothyroidism, defined by the presence of serum anti-thyroglobulin (TgAb) and anti-thyroid peroxidase (TPOAb) antibodies directed against thyroid cells (Waliszewska-Pros And Ejma 2022)

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