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Furthermore, GPER can affect the redox state within cells, influencing their oxygen utilization and thereby enhancing tumor cell adaptability in hypoxic environments [231]

Key Takeaway: GHK-Cu acts through multiple overlapping mechanisms fibroblast activation, controlled copper delivery, antioxidant signaling, and broad gene-expression modulation

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In vitro, SFN has been shown to be a potent chemopreventive agent and has been demonstrated to target multiple cellular mechanisms [81]

2014, Haje & Naoom 2015)