Furthermore, to refine the experimentally determined structural model and explore interaction dynamics, we conducted extensive MD simulations
This aging mechanism is closely related to various common diseases, including atherosclerosis, hypertension, chronic obstructive pulmonary disease, diabetes, and neurodegenerative disorders ( Current senolytic agents are primarily employed in cancer therapies, such as doxorubicin, trametinib, and cell cycle-targeting drugs like palbociclib ( Although studies have shown that FOXO4-DRI can block the binding of P53 to FOXO4, thereby promoting the apoptosis of senescent cells, the effect of FOXO4-DRI is not limited to alleviating the aging of certain organs
Within eukaryotic cells, a-helical ACPs can induce mitochondrial infiltration and swelling, releasing cytochrome c (Cytc), ultimately leading to cancer cell apoptosis
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