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During hypoglycaemia, insulin secretion is reduced and glucagon secretion is not inhibited

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Hypertrophic AT secretes more matrix metalloproteinase 9, leading to elastin fiber and ECM degradation, thereby diminishing skin structural integrity and its ability to resist vertical gravitational vectors

For pen users, the pen needle handles both jobs, and a 4 mm 32G is the modern default

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Important safety considerations include a boxed warning for medullary thyroid carcinoma risk (contraindicated in patients with personal/family history of MTC or Multiple Endocrine Neoplasia syndrome type 2), and warnings regarding pancreatitis, gallbladder disease, and hypoglycemia risk when used with insulin or sulfonylureas