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1,2 These drugs act on both the central nervous system and the gastrointestinal tract, promoting satiety and reducing food intake, as demonstrated by brain imaging studies using GLP-1-specific tracers

Both peptides bind to the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a) on pituitary somatotropes, triggering pulsatile GH release

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Discuss contraindications and medical history thoroughly with your provider

A groundbreaking study conducted by Chami et al ., using large-scale whole-genome analysis, revealed that obesity has a polygenic basis and identified at least eight genetic subtypes with distinct profiles of complication risk

doi:10.2337/diabetes.52.6.1449 163