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Zhihong Y, Chen W, Qianqian Z, Lidan S, Qiang Z, Jing H, et al

According to Lillys release, the trial met its primary endpoint: participants titrating up to the highest orforglipron dose lost 27.3 lb (12.4%) of body weight at 72 weeks versus about 0.9% weight loss with placebo

2024;134(2):e175634

Increasing fiber intake and fluid intake can also help prevent constipation

Last reviewed: June 8, 2026 Last updated: June 8, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

The primary endpoint of weight loss of at least 5% occurred in 85% of the tirzepatide 5 mg group, 89% of the tirzepatide 10 mg group and 91% of participants in the tirzepatide 15 mg group