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Since the start of the SARS outbreak in China in November 2002, Chen has been researching animal immune responses and the immunopathogenesis of coronaviruses

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In the context of hepatic IR associated with non-alcoholic fatty liver disease (NAFLD), this molecular pathway becomes dysregulated, leading to impaired suppression of hepatic gluconeogenesis

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Acetyl-CoA then combines with oxaloacetate forming citrate, which exits the mitochondria to proceed toward fatty acid synthesis in the cytosol