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[13] [14] For medicines with a narrow therapeutic index, consider appropriate spacing of doses and additional monitoring

Changes in waist circumference ranged from 2.1cm (~0.8in) to 10.2cm (~4in) for tirzepatide, as compared to 1.3cm (~0.5in) for placebo [12]

It is also involved in detoxification by binding to fat-soluble toxins, such as heavy metals, solvents, and pesticides, and transforming them into a water-soluble form that can be excreted in urine

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Understanding what each one does, and what happens when it runs low, helps you recognize problems before they become serious