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American journal of human genetics 62, 10441051, doi:10.1086/301825 (1998)

Maximal antioxidant protection was observed only when both antioxidants were simultaneously present, indicating that both antioxidants are needed for cell survival against oxidative stress.

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In contrast, ketogenesisas induced by lysine via another receptor called PPAR alphaprevents differentiation into fat, thus increasing bone mass