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Journal of Chemical Biology, 2 (3), 131151
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Brief Introduction and Physiological Function of Glucagon Like Peptide-1 Receptor Agonists Glucagon like peptide-1 (GLP-1) is the second incretin identified in 1983
These scientific breakthroughs coincided with obesity becoming a top global health issue in the past 1520 years, driving a perfect storm for adoption
It is noteworthy that a behavioral analysis of Glp1r +/+ , Glp1r +/ and Glp1r/ mouse phenotypes and hippocampal Glp1r gene transfer demonstrated that deficiency of this receptor results in decrements in the acquisition of associative contextual learning which can be improved by hippocampal Glp1r somatic cell gene transfer [45]
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