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Thiamine also appears to have direct anti-inflammatory effects in the gut of ruminant animals, showing a reduction in intestinal permeability through enhanced production of barrier proteins, protection against bacterial lipopolysaccharide-induced inflammation, and improved barrier function

The general consensus is that a day early is fine, while consistently shortening the interval between doses is not recommended as it increases side effect risk

doi: 10.3389/fimmu.2023.1139589 Received 07 January 2023 Accepted 20 March 2023 Published 18 April 2023 Volume 14 - 2023 Edited by Qun Zhao, Fourth Hospital of Hebei Medical University, China Reviewed by Laiping Zhong, Shanghai Jiao Tong University, China

The maintenance dose can be 1.7 mg or 2.5 mg weekly

[1] [3] Dehydration from gastrointestinal losses can increase the risk of acute kidney injury, making adequate fluid intake essential

The toner forms a protective moisture film on the skin, allowing for faster absorption and long-lasting hydration