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11,12 Notably, the potential neuroprotective properties of GLP-1 RAs extend to conditions like Alzheimer disease (AD) and Parkinson disease by ameliorating motor impairment and curtailing oxidative stress, inflammation, and apoptosis

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The drug is currently progressing through Phase 3 clinical trials under the TRIUMPH programme, which is evaluating its efficacy and safety across a range of populations

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In populations with lower levels of obesity and more moderate obesity trends, the projected mortality improvements would be lower

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Back Marks, V (2020) 'The early history of GIP 19692000: From enterogastrone to major metabolic hormone', Peptides , 125, 170276

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How much weight can I lose on retatrutide?: Clinical Trials & Weight Loss Results The weight loss results from retatrutide clinical trials have been impressive, though its important to remember these are still early-stage studies with relatively small groups of participants

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At 12 months, weight loss persisted at around 4%, with variability between agents, most notably liraglutide

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