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These effects reflect the GI slowing caused by delayed gastric emptying and tend to resolve as the body adapts to the compound

GLP-1 receptor agonists have changed the way clinicians can address these conditions helping millions lose weight and improve metabolic health

Last reviewed: June 9, 2026 Last updated: June 9, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

The outstanding question is long-term cardiovascular safety

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If a skin condition develops at a preferred injection site, rotate to an unaffected area and allow the condition to resolve completely before returning