SalcedoI,TweedieD,LiYetal.Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders.Br J Pharmacol.2012;166:158699
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E N D Presentation Transcript INCRETINS Glucagon-like Peptide 1 (GLP-1)and Glucose-Dependent Insulinotrophic Polypeptide (GIP) account for ~90% of the incretin effect In response to equivalent hyperglycemic stimuli, ORAL glucose elicits a greater insulin response than IV glucose Insulin Glucose-Stimulated Secretion of Insulin Glucose GLUT2 Pancreatic Cell SUR Glucose Potassium channel GK K+ Pyruvate GLP-1 ATP + ATP GIP TCA Cycle* AC + Calcium channel cAMP [Ca2+] Amplifying Triggering AC = adenylyl cyclase
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Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats
The Triple-Agonist Breakthrough Retatrutide (LY3437943), developed by Eli Lilly, is an investigational triple-agonist peptide that activates three metabolic receptors simultaneously: GLP-1, GIP, and the glucagon receptor
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