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Self-medicating or making changes without supervision can lead to adverse outcomes and suboptimal disease control

GLP-1RAs are a novel class of glucose-lowering agents that mimic the physiological actions of endogenous GLP-1 by enhancing insulin secretion, reducing glucagon release, and acting on the brain to inhibit gastrointestinal motility, thereby slowing nutrient absorption

These risks can be more pronounced due to the nature of asthma and its treatments

However, patients should be screened for contraindications, such as a history of pancreatitis or certain gastrointestinal conditions

adjusted eGFR decline = 14.48 eGFR at baseline 0.087 + 1.504 (if female) 0.069 Age + 0.052 BW - 0.097 BMI - 0.018 SBP - 0.032 DBP - 0.048 HbA1c (mol/L) + Treatment periods(months) 0.022

Blood sugar management, metabolic health, kidney health, heart risk, and medication alternatives are medical decisions