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Regarding the blinding within performance and detection bias, we found a high risk of bias in ten studies [16, 23, 25,26,27, 33, 39, 41, 48, 49]

If you experience these symptoms, discuss a dose reduction with your provider rather than simply pushing through

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Please contact your doctor ASAP and seek in-person care immediately if a side effect becomes problematic or you experience: Severe nausea and/or vomiting resulting in dehydration- it is important to stay well hydrated and drink plenty of fluids while on this medication Kidney problems/kidney failure - vomiting, nausea, diarrhea can cause dehydration and kidney issues and make kidney problems worse in individuals who have pre-existing kidney conditions

The FDAs message is stark but constructive: keep using your brains