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10.1016/j.ejphar.2021.174603 204 WeiM.GaoY.ChengD.ZhangH.ZhangW.ShenY.et al (2022)

About this article Cite this article LoPiccolo, J., Gusev, A., Christiani, D.C

Using medication beyond its expiration date carries real risks: active ingredient concentration may fall below therapeutic levels, and bacterial contamination becomes more likely

However, there may also be neurohormonal mechanisms for its release involving stimulation from the vagus nerve that are less understood

SFT: subcutaneous fatty tissue

39 The outcome of these studies reinforces the notion that the intestinal epithelium is essential for separating luminal antigens from mucosal immune components, and that its disruption by altered proliferation/apoptosis ratio can result in immune activation and inflammation (Figure 1)