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Cagrilintide also has one of the lowest GI odds ratios among the incretin and amylin compound class in a 2025 Bayesian network meta-analysis of multi-target obesity therapies the relevance for the stack is that adding cagrilintide to retatrutide may not compound GI burden as severely as adding a second GLP-1 agonist would

Tirzepatide produces average weight loss of 16% to 22.5% of body weight over 72 weeks in clinical trials

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Rather than simply masking signs of aging, the peptide appears to support some of the biological systems that influence skin health beneath the surface

& Castenholz, R