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Three affected individuals from a kindred carried two previously unreported missense changes, p.T452I and p.G453V

Provider and patient attitudes vary, but there exists much more reluctance to initiate pharmacotherapy for obesity than for other chronic diseases such as hypertension, type 2 diabetes, or hyperlipidemia

Marshall NE, Abrams B, Barbour LA, et al

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Such insights reaffirm the importance of GLP-1Rs in the dLS and pave the way for targeted interventions in the future