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IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis

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2013 Jul 10;31(20):2627-33

Therefore, targeting the HIF signaling pathway and its regulated downstream gene expression has become a potential strategy for treating hypoxia-related diseases

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Chronic potentiation of a proliferative pathway is a reason researchers flag oncological caution but that is mechanistic reasoning, not a demonstrated effect