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Preclinical doses

Unlike Hydroquinone, it is possible to use Tretinoin continuously long term as long as you can tolerate it

However, this is generally not a concern in the United States, says Kovalenko

Tumor necrosis factor-alpha (TNF-), found in high concentrations in the blood, feces, and inflamed intestinal mucosa of patients with IBD, is implicated in the pathogenesis of UC and Crohn's disease (17)