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We and others have shown that long-acting GIPR agonists have a preserved ability to decrease body weight and food intake in Glp-1r- deficient mice 15,18 , which is lost in obese mice with Nestin-Cre -mediated neuronal loss of Gipr 15

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But as Francis Colonna, a senior obesity medicine nurse practitioner at Northwell Health, points out, it can be taken at any time of day, with or without food or water restrictions

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