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However, none of the therapeutic candidates have been successful so far [10-12] , with the major impediment for most being a failure to cross the blood-brain barrier

However, several over-the-counter dietary and herbal products, marketed to support thyroid health and to lose weight, contain excessively high amounts of iodine, sometimes above the TUL, and their use should be discouraged, according to the ATA recommendations [22, 34, 52]

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