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A total of 6042 T2D subjects with established cardiovascular risk from 600 international institutions were randomly assigned to receive either glimepiride or linagliptin, and were followed up for an average of 6 years

However, side effects such as nausea, bloating, constipation, fatigue, and appetite suppression can make treatment difficult for some individuals

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Uptake is being accelerated by increased patient compliance and a preference for non-invasive treatments