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In the NEJM Phase 2 trial, participants assigned to an initial dose of 4 mg experienced significantly more adverse events than those who started at 2 mg, even when both groups ultimately reached the same target dose

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Foer and colleagues aimed to fill that gap by examining serum periostin, a biomarker strongly associated with airway inflammation induced by IL-4, IL-13, and transforming growth factor- [100]

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