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[22] [23] Baseline assessment should be considered before initiating tirzepatide in high-risk patients, including those over 65 years of age, individuals with pre-existing gastrointestinal disorders, patients on concurrent metformin or acid-suppressing medications, and those following restrictive diets

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A superior molecule with the same evidence base If a next-generation regenerative active emerged with comparable safety, broader mechanism evidence, and better intrinsic delivery, the focus would shift

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