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Aghaamoo S, Zandbina A, Saffarieh E, Nassiri S

Better sleep from weight loss and reduced sleep apnea Poor sleep and low energy are inseparable

In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

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There are other factors however which are more difficult to avoid such as air pollution, excessive exposure to pesticides, herbicides, or heavy metals

Its approval is a big step forward