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While GLP-1 drugs aren't specifically licensed for post-op weight regain, research is emerging

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[39] One major limitation in the use of GLP-1 peptide was its extremely short half-life (1.55 minutes) due to rapid cleavage and degradation by the enzyme dipeptidyl peptidase-4 (DPP-4), [40] so DPP-4 resistant GLP-1 RAs were developed for longer-lasting effects