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For example, patients with certain GLP1R variants (rs6923761) or FTO polymorphisms (rs9939609) demonstrate stronger appetite suppression and greater sustained weight loss on tirzepatide than semaglutide

4 Some countries have their own restrictions, and a few ask for a doctors letter confirming what the medication is and why you take it

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The additional GIP component can lead to more significant metabolic changes and weight loss, which may result in a more pronounced adjustment period and temporary fatigue for some individuals

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