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Protein Folding versus Prediction of Protein Structure Protein Folding The protein folding problem embraces two questions: 51 first, the conceptual question of how a proteins amino acid sequence dictates its 3D atomic structure, and second, how, starting from a single amino acid sequence, to successfully predict the 3D structure, without using information related to other available (homologous, same family) sequences nor structures of any related sequences

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Note how much of the strongest evidence is either animal-only or for an approved indication other than fitness