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The combination of dropping estrogen, the decline in physical activity that tends to happen as you age, and side effects of menopause like trouble sleeping all combine for a slow-and-steady weight gain

they do not predict how you will respond to any specific compound

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In current clinical trials, retatrutide side effects have been mild to moderate and most often included: Nausea Diarrhea Vomiting Constipation As noted above, in many of these randomized trials there is a chance that you will be receiving a placebo, so no active drug at all