Beneficial commensals are depleted, while opportunistic species expand, altering local immune surveillance and perpetuating chronic inflammation
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Each session typically lasts 15-20 minutes
Non-coding RNAs add further regulatory complexity: specific miRNA profiles (let-7 family, miR-372373 cluster) correlate with oocyte competence and embryo potential [170,171,172,173,174,175,176], while long non-coding RNAs such as NORAD and NEAT1 regulate chromatin organization [177,178,179,180]
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Beyond HCV, PYC also modulates host factors implicated in viral replication and immune regulation, including long non-coding IFN-induced protein-44 (lnc-IFI-44), polycystic kidney disease 1-like 3 (Pkd1l3), and ubiquitin-specific peptidase 31 (Usp31) (Ide et al., 2022)